Adalat Gits 30
Brand names,
Adalat Gits 30
Analogs
Adalat Gits 30
Brand Names Mixture
Adalat Gits 30
Chemical_Formula
C17H18N2O6
Adalat Gits 30
RX_link
http://www.rxlist.com/cgi/generic2/nifedip.htm
Adalat Gits 30
fda sheet
Adalat Gits 30
msds (material safety sheet)
Adalat Gits 30
Synthesis Reference
Bossert, Vater, U.S. Pat. 3,485,847 (1969)
Adalat Gits 30
Molecular Weight
346.335 g/mol
Adalat Gits 30
Melting Point
172 - 174 oC
Adalat Gits 30
H2O Solubility
Insoluble
Adalat Gits 30
State
Solid
Adalat Gits 30
LogP
2.343
Adalat Gits 30
Dosage Forms
Capsule; Tablet; Tablet (extended-release)
Adalat Gits 30
Indication
For the management of vasospastic angina, chronic stable angina and hypertension.
Adalat Gits 30
Pharmacology
Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.
Adalat Gits 30
Absorption
Rapidly and fully absorbed following oral administration.
Adalat Gits 30
side effects and Toxicity
Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD50=494 mg/kg (orally in mice); LD50=1022 mg/kg (orally in rats)
Adalat Gits 30
Patient Information
Adalat Gits 30
Organisms Affected
Humans and other mammals