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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C17H18N2O6
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RX_link
http://www.rxlist.com/cgi/generic2/nifedip.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
Bossert, Vater, U.S. Pat. 3,485,847 (1969)
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Molecular Weight
346.335 g/mol
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Melting Point
172 - 174 oC
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H2O Solubility
Insoluble
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State
Solid
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LogP
2.343
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Dosage Forms
Capsule; Tablet; Tablet (extended-release)
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Indication
For the management of vasospastic angina, chronic stable angina and hypertension.
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Pharmacology
Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.
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Absorption
Rapidly and fully absorbed following oral administration.
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side effects and Toxicity
Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD50=494 mg/kg (orally in mice); LD50=1022 mg/kg (orally in rats)
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Patient Information
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Organisms Affected
Humans and other mammals