Procardia XL
Brand names,
Procardia XL
Analogs
Procardia XL
Brand Names Mixture
Procardia XL
Chemical_Formula
C17H18N2O6
Procardia XL
RX_link
http://www.rxlist.com/cgi/generic2/nifedip.htm
Procardia XL
fda sheet
Procardia XL
msds (material safety sheet)
Procardia XL
Synthesis Reference
Bossert, Vater, U.S. Pat. 3,485,847 (1969)
Procardia XL
Molecular Weight
346.335 g/mol
Procardia XL
Melting Point
172 - 174 oC
Procardia XL
H2O Solubility
Insoluble
Procardia XL
State
Solid
Procardia XL
LogP
2.343
Procardia XL
Dosage Forms
Capsule; Tablet; Tablet (extended-release)
Procardia XL
Indication
For the management of vasospastic angina, chronic stable angina and hypertension.
Procardia XL
Pharmacology
Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.
Procardia XL
Absorption
Rapidly and fully absorbed following oral administration.
Procardia XL
side effects and Toxicity
Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD50=494 mg/kg (orally in mice); LD50=1022 mg/kg (orally in rats)
Procardia XL
Patient Information
Procardia XL
Organisms Affected
Humans and other mammals