Nifipen

Nifipen Brand names, Nifipen Analogs

Nifipen Brand Names Mixture

No information avaliable

Nifipen Chemical_Formula

C₁₇H₁₈N₂O₆

Nifipen RX_link

http://www.rxlist.com/cgi/generic2/nifedip.htm

Nifipen fda sheet

Nifipen FDA

Nifipen msds (material safety sheet)

Nifipen MSDS

Nifipen Synthesis Reference

Bossert, Vater, U.S. Pat. 3,485,847 (1969)

Nifipen Molecular Weight

346.335 g/mol

Nifipen Melting Point

172 - 174 ^oC

Nifipen H₂O Solubility

Insoluble

Nifipen State

Solid

Nifipen LogP

2.343

Nifipen Dosage Forms

Capsule; Tablet; Tablet (extended-release)

Nifipen Indication

For the management of vasospastic angina, chronic stable angina and hypertension.

Nifipen Pharmacology

Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.

Nifipen Absorption

Rapidly and fully absorbed following oral administration.

Nifipen side effects and Toxicity

Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD₅₀=494 mg/kg (orally in mice); LD₅₀=1022 mg/kg (orally in rats)

Nifipen Patient Information

Nifipen Organisms Affected

Humans and other mammals