Pidilat
Brand names,
Pidilat
Analogs
Pidilat
Brand Names Mixture
Pidilat
Chemical_Formula
C17H18N2O6
Pidilat
RX_link
http://www.rxlist.com/cgi/generic2/nifedip.htm
Pidilat
fda sheet
Pidilat
msds (material safety sheet)
Pidilat
Synthesis Reference
Bossert, Vater, U.S. Pat. 3,485,847 (1969)
Pidilat
Molecular Weight
346.335 g/mol
Pidilat
Melting Point
172 - 174 oC
Pidilat
H2O Solubility
Insoluble
Pidilat
State
Solid
Pidilat
LogP
2.343
Pidilat
Dosage Forms
Capsule; Tablet; Tablet (extended-release)
Pidilat
Indication
For the management of vasospastic angina, chronic stable angina and hypertension.
Pidilat
Pharmacology
Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.
Pidilat
Absorption
Rapidly and fully absorbed following oral administration.
Pidilat
side effects and Toxicity
Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD50=494 mg/kg (orally in mice); LD50=1022 mg/kg (orally in rats)
Pidilat
Patient Information
Pidilat
Organisms Affected
Humans and other mammals