N1fedilat
Brand names,
N1fedilat
Analogs
N1fedilat
Brand Names Mixture
N1fedilat
Chemical_Formula
C17H18N2O6
N1fedilat
RX_link
http://www.rxlist.com/cgi/generic2/nifedip.htm
N1fedilat
fda sheet
N1fedilat
msds (material safety sheet)
N1fedilat
Synthesis Reference
Bossert, Vater, U.S. Pat. 3,485,847 (1969)
N1fedilat
Molecular Weight
346.335 g/mol
N1fedilat
Melting Point
172 - 174 oC
N1fedilat
H2O Solubility
Insoluble
N1fedilat
State
Solid
N1fedilat
LogP
2.343
N1fedilat
Dosage Forms
Capsule; Tablet; Tablet (extended-release)
N1fedilat
Indication
For the management of vasospastic angina, chronic stable angina and hypertension.
N1fedilat
Pharmacology
Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.
N1fedilat
Absorption
Rapidly and fully absorbed following oral administration.
N1fedilat
side effects and Toxicity
Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD50=494 mg/kg (orally in mice); LD50=1022 mg/kg (orally in rats)
N1fedilat
Patient Information
N1fedilat
Organisms Affected
Humans and other mammals