Kordafen
Brand names,
Kordafen
Analogs
Kordafen
Brand Names Mixture
Kordafen
Chemical_Formula
C17H18N2O6
Kordafen
RX_link
http://www.rxlist.com/cgi/generic2/nifedip.htm
Kordafen
fda sheet
Kordafen
msds (material safety sheet)
Kordafen
Synthesis Reference
Bossert, Vater, U.S. Pat. 3,485,847 (1969)
Kordafen
Molecular Weight
346.335 g/mol
Kordafen
Melting Point
172 - 174 oC
Kordafen
H2O Solubility
Insoluble
Kordafen
State
Solid
Kordafen
LogP
2.343
Kordafen
Dosage Forms
Capsule; Tablet; Tablet (extended-release)
Kordafen
Indication
For the management of vasospastic angina, chronic stable angina and hypertension.
Kordafen
Pharmacology
Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.
Kordafen
Absorption
Rapidly and fully absorbed following oral administration.
Kordafen
side effects and Toxicity
Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD50=494 mg/kg (orally in mice); LD50=1022 mg/kg (orally in rats)
Kordafen
Patient Information
Kordafen
Organisms Affected
Humans and other mammals