Nicardia
Brand names,
Nicardia
Analogs
Nicardia
Brand Names Mixture
Nicardia
Chemical_Formula
C17H18N2O6
Nicardia
RX_link
http://www.rxlist.com/cgi/generic2/nifedip.htm
Nicardia
fda sheet
Nicardia
msds (material safety sheet)
Nicardia
Synthesis Reference
Bossert, Vater, U.S. Pat. 3,485,847 (1969)
Nicardia
Molecular Weight
346.335 g/mol
Nicardia
Melting Point
172 - 174 oC
Nicardia
H2O Solubility
Insoluble
Nicardia
State
Solid
Nicardia
LogP
2.343
Nicardia
Dosage Forms
Capsule; Tablet; Tablet (extended-release)
Nicardia
Indication
For the management of vasospastic angina, chronic stable angina and hypertension.
Nicardia
Pharmacology
Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.
Nicardia
Absorption
Rapidly and fully absorbed following oral administration.
Nicardia
side effects and Toxicity
Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD50=494 mg/kg (orally in mice); LD50=1022 mg/kg (orally in rats)
Nicardia
Patient Information
Nicardia
Organisms Affected
Humans and other mammals