Adalat
Brand names,
Adalat
Analogs
Adalat
Brand Names Mixture
Adalat
Chemical_Formula
C17H18N2O6
Adalat
RX_link
http://www.rxlist.com/cgi/generic2/nifedip.htm
Adalat
fda sheet
Adalat
msds (material safety sheet)
Adalat
Synthesis Reference
Bossert, Vater, U.S. Pat. 3,485,847 (1969)
Adalat
Molecular Weight
346.335 g/mol
Adalat
Melting Point
172 - 174 oC
Adalat
H2O Solubility
Insoluble
Adalat
State
Solid
Adalat
LogP
2.343
Adalat
Dosage Forms
Capsule; Tablet; Tablet (extended-release)
Adalat
Indication
For the management of vasospastic angina, chronic stable angina and hypertension.
Adalat
Pharmacology
Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.
Adalat
Absorption
Rapidly and fully absorbed following oral administration.
Adalat
side effects and Toxicity
Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD50=494 mg/kg (orally in mice); LD50=1022 mg/kg (orally in rats)
Adalat
Patient Information
Adalat
Organisms Affected
Humans and other mammals