Megalat
Brand names,
Megalat
Analogs
Megalat
Brand Names Mixture
Megalat
Chemical_Formula
C17H18N2O6
Megalat
RX_link
http://www.rxlist.com/cgi/generic2/nifedip.htm
Megalat
fda sheet
Megalat
msds (material safety sheet)
Megalat
Synthesis Reference
Bossert, Vater, U.S. Pat. 3,485,847 (1969)
Megalat
Molecular Weight
346.335 g/mol
Megalat
Melting Point
172 - 174 oC
Megalat
H2O Solubility
Insoluble
Megalat
State
Solid
Megalat
LogP
2.343
Megalat
Dosage Forms
Capsule; Tablet; Tablet (extended-release)
Megalat
Indication
For the management of vasospastic angina, chronic stable angina and hypertension.
Megalat
Pharmacology
Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.
Megalat
Absorption
Rapidly and fully absorbed following oral administration.
Megalat
side effects and Toxicity
Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD50=494 mg/kg (orally in mice); LD50=1022 mg/kg (orally in rats)
Megalat
Patient Information
Megalat
Organisms Affected
Humans and other mammals