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Adapine Brand names, Adapine Analogs

Adapine Brand Names Mixture

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Adapine Chemical_Formula


Adapine RX_link

Adapine fda sheet

Adapine FDA

Adapine msds (material safety sheet)

Adapine MSDS

Adapine Synthesis Reference

Bossert, Vater, U.S. Pat. 3,485,847 (1969)

Adapine Molecular Weight

346.335 g/mol

Adapine Melting Point

172 - 174 oC

Adapine H2O Solubility


Adapine State


Adapine LogP


Adapine Dosage Forms

Capsule; Tablet; Tablet (extended-release)

Adapine Indication

For the management of vasospastic angina, chronic stable angina and hypertension.

Adapine Pharmacology

Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.

Adapine Absorption

Rapidly and fully absorbed following oral administration.

Adapine side effects and Toxicity

Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD50=494 mg/kg (orally in mice); LD50=1022 mg/kg (orally in rats)

Adapine Patient Information

Adapine Organisms Affected

Humans and other mammals