Adalate
Brand names,
Adalate
Analogs
Adalate
Brand Names Mixture
Adalate
Chemical_Formula
C17H18N2O6
Adalate
RX_link
http://www.rxlist.com/cgi/generic2/nifedip.htm
Adalate
fda sheet
Adalate
msds (material safety sheet)
Adalate
Synthesis Reference
Bossert, Vater, U.S. Pat. 3,485,847 (1969)
Adalate
Molecular Weight
346.335 g/mol
Adalate
Melting Point
172 - 174 oC
Adalate
H2O Solubility
Insoluble
Adalate
State
Solid
Adalate
LogP
2.343
Adalate
Dosage Forms
Capsule; Tablet; Tablet (extended-release)
Adalate
Indication
For the management of vasospastic angina, chronic stable angina and hypertension.
Adalate
Pharmacology
Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.
Adalate
Absorption
Rapidly and fully absorbed following oral administration.
Adalate
side effects and Toxicity
Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD50=494 mg/kg (orally in mice); LD50=1022 mg/kg (orally in rats)
Adalate
Patient Information
Adalate
Organisms Affected
Humans and other mammals