Corinfar
Brand names,
Corinfar
Analogs
Corinfar
Brand Names Mixture
Corinfar
Chemical_Formula
C17H18N2O6
Corinfar
RX_link
http://www.rxlist.com/cgi/generic2/nifedip.htm
Corinfar
fda sheet
Corinfar
msds (material safety sheet)
Corinfar
Synthesis Reference
Bossert, Vater, U.S. Pat. 3,485,847 (1969)
Corinfar
Molecular Weight
346.335 g/mol
Corinfar
Melting Point
172 - 174 oC
Corinfar
H2O Solubility
Insoluble
Corinfar
State
Solid
Corinfar
LogP
2.343
Corinfar
Dosage Forms
Capsule; Tablet; Tablet (extended-release)
Corinfar
Indication
For the management of vasospastic angina, chronic stable angina and hypertension.
Corinfar
Pharmacology
Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.
Corinfar
Absorption
Rapidly and fully absorbed following oral administration.
Corinfar
side effects and Toxicity
Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD50=494 mg/kg (orally in mice); LD50=1022 mg/kg (orally in rats)
Corinfar
Patient Information
Corinfar
Organisms Affected
Humans and other mammals