Ecodipi
Brand names,
Ecodipi
Analogs
Ecodipi
Brand Names Mixture
Ecodipi
Chemical_Formula
C17H18N2O6
Ecodipi
RX_link
http://www.rxlist.com/cgi/generic2/nifedip.htm
Ecodipi
fda sheet
Ecodipi
msds (material safety sheet)
Ecodipi
Synthesis Reference
Bossert, Vater, U.S. Pat. 3,485,847 (1969)
Ecodipi
Molecular Weight
346.335 g/mol
Ecodipi
Melting Point
172 - 174 oC
Ecodipi
H2O Solubility
Insoluble
Ecodipi
State
Solid
Ecodipi
LogP
2.343
Ecodipi
Dosage Forms
Capsule; Tablet; Tablet (extended-release)
Ecodipi
Indication
For the management of vasospastic angina, chronic stable angina and hypertension.
Ecodipi
Pharmacology
Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.
Ecodipi
Absorption
Rapidly and fully absorbed following oral administration.
Ecodipi
side effects and Toxicity
Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD50=494 mg/kg (orally in mice); LD50=1022 mg/kg (orally in rats)
Ecodipi
Patient Information
Ecodipi
Organisms Affected
Humans and other mammals