Fenamon Sr
Brand names,
Fenamon Sr
Analogs
Fenamon Sr
Brand Names Mixture
Fenamon Sr
Chemical_Formula
C17H18N2O6
Fenamon Sr
RX_link
http://www.rxlist.com/cgi/generic2/nifedip.htm
Fenamon Sr
fda sheet
Fenamon Sr
msds (material safety sheet)
Fenamon Sr
Synthesis Reference
Bossert, Vater, U.S. Pat. 3,485,847 (1969)
Fenamon Sr
Molecular Weight
346.335 g/mol
Fenamon Sr
Melting Point
172 - 174 oC
Fenamon Sr
H2O Solubility
Insoluble
Fenamon Sr
State
Solid
Fenamon Sr
LogP
2.343
Fenamon Sr
Dosage Forms
Capsule; Tablet; Tablet (extended-release)
Fenamon Sr
Indication
For the management of vasospastic angina, chronic stable angina and hypertension.
Fenamon Sr
Pharmacology
Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.
Fenamon Sr
Absorption
Rapidly and fully absorbed following oral administration.
Fenamon Sr
side effects and Toxicity
Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD50=494 mg/kg (orally in mice); LD50=1022 mg/kg (orally in rats)
Fenamon Sr
Patient Information
Fenamon Sr
Organisms Affected
Humans and other mammals