Chronadalate
Brand names,
Chronadalate
Analogs
Chronadalate
Brand Names Mixture
Chronadalate
Chemical_Formula
C17H18N2O6
Chronadalate
RX_link
http://www.rxlist.com/cgi/generic2/nifedip.htm
Chronadalate
fda sheet
Chronadalate
msds (material safety sheet)
Chronadalate
Synthesis Reference
Bossert, Vater, U.S. Pat. 3,485,847 (1969)
Chronadalate
Molecular Weight
346.335 g/mol
Chronadalate
Melting Point
172 - 174 oC
Chronadalate
H2O Solubility
Insoluble
Chronadalate
State
Solid
Chronadalate
LogP
2.343
Chronadalate
Dosage Forms
Capsule; Tablet; Tablet (extended-release)
Chronadalate
Indication
For the management of vasospastic angina, chronic stable angina and hypertension.
Chronadalate
Pharmacology
Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.
Chronadalate
Absorption
Rapidly and fully absorbed following oral administration.
Chronadalate
side effects and Toxicity
Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD50=494 mg/kg (orally in mice); LD50=1022 mg/kg (orally in rats)
Chronadalate
Patient Information
Chronadalate
Organisms Affected
Humans and other mammals