Cordalat
Brand names,
Cordalat
Analogs
Cordalat
Brand Names Mixture
Cordalat
Chemical_Formula
C17H18N2O6
Cordalat
RX_link
http://www.rxlist.com/cgi/generic2/nifedip.htm
Cordalat
fda sheet
Cordalat
msds (material safety sheet)
Cordalat
Synthesis Reference
Bossert, Vater, U.S. Pat. 3,485,847 (1969)
Cordalat
Molecular Weight
346.335 g/mol
Cordalat
Melting Point
172 - 174 oC
Cordalat
H2O Solubility
Insoluble
Cordalat
State
Solid
Cordalat
LogP
2.343
Cordalat
Dosage Forms
Capsule; Tablet; Tablet (extended-release)
Cordalat
Indication
For the management of vasospastic angina, chronic stable angina and hypertension.
Cordalat
Pharmacology
Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.
Cordalat
Absorption
Rapidly and fully absorbed following oral administration.
Cordalat
side effects and Toxicity
Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD50=494 mg/kg (orally in mice); LD50=1022 mg/kg (orally in rats)
Cordalat
Patient Information
Cordalat
Organisms Affected
Humans and other mammals