Nifedipres
Brand names,
Nifedipres
Analogs
Nifedipres
Brand Names Mixture
Nifedipres
Chemical_Formula
C17H18N2O6
Nifedipres
RX_link
http://www.rxlist.com/cgi/generic2/nifedip.htm
Nifedipres
fda sheet
Nifedipres
msds (material safety sheet)
Nifedipres
Synthesis Reference
Bossert, Vater, U.S. Pat. 3,485,847 (1969)
Nifedipres
Molecular Weight
346.335 g/mol
Nifedipres
Melting Point
172 - 174 oC
Nifedipres
H2O Solubility
Insoluble
Nifedipres
State
Solid
Nifedipres
LogP
2.343
Nifedipres
Dosage Forms
Capsule; Tablet; Tablet (extended-release)
Nifedipres
Indication
For the management of vasospastic angina, chronic stable angina and hypertension.
Nifedipres
Pharmacology
Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.
Nifedipres
Absorption
Rapidly and fully absorbed following oral administration.
Nifedipres
side effects and Toxicity
Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD50=494 mg/kg (orally in mice); LD50=1022 mg/kg (orally in rats)
Nifedipres
Patient Information
Nifedipres
Organisms Affected
Humans and other mammals