Fenihidine
Brand names,
Fenihidine
Analogs
Fenihidine
Brand Names Mixture
Fenihidine
Chemical_Formula
C17H18N2O6
Fenihidine
RX_link
http://www.rxlist.com/cgi/generic2/nifedip.htm
Fenihidine
fda sheet
Fenihidine
msds (material safety sheet)
Fenihidine
Synthesis Reference
Bossert, Vater, U.S. Pat. 3,485,847 (1969)
Fenihidine
Molecular Weight
346.335 g/mol
Fenihidine
Melting Point
172 - 174 oC
Fenihidine
H2O Solubility
Insoluble
Fenihidine
State
Solid
Fenihidine
LogP
2.343
Fenihidine
Dosage Forms
Capsule; Tablet; Tablet (extended-release)
Fenihidine
Indication
For the management of vasospastic angina, chronic stable angina and hypertension.
Fenihidine
Pharmacology
Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.
Fenihidine
Absorption
Rapidly and fully absorbed following oral administration.
Fenihidine
side effects and Toxicity
Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD50=494 mg/kg (orally in mice); LD50=1022 mg/kg (orally in rats)
Fenihidine
Patient Information
Fenihidine
Organisms Affected
Humans and other mammals