Velium
Brand names,
Velium
Analogs
Velium
Brand Names Mixture
Velium
Chemical_Formula
C16H13ClN2O
Velium
RX_link
http://www.rxlist.com/cgi/generic/diazepam.htm
Velium
fda sheet
Velium
msds (material safety sheet)
Velium
Synthesis Reference
Reeder, Sternbach; U.S. Pat. 3,371,085 (1968)
Velium
Molecular Weight
284.74 g/mol
Velium
Melting Point
125-126oC
Velium
H2O Solubility
Slightly soluble (50 mg/L)
Velium
State
solid
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LogP
2.988
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Dosage Forms
Tablets; Injectable solution
Velium
Indication
Used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome.
Velium
Pharmacology
Diazepam, a benzodiazepine, generates the same active metabolite as chlordiazepoxide and clorazepate. In animals, diazepam appears to act on parts of the limbic system, the thalamus and hypothalamus, and induces calming effects. Diazepam, unlike chlorpromazine and reserpine, has no demonstrable peripheral autonomic blocking action, nor does it produce extrapyramidal side effects; however, animals treated with diazepam do have a transient ataxia at higher doses. Diazepam was found to have transient cardiovascular depressor effects in dogs. Long-term experiments in rats revealed no disturbances of endocrine function. Injections into animals have produced localized irritation of tissue surrounding injection sites and some thickening of veins after intravenous use.
Velium
Absorption
Essentially complete, with a bioavailability of 93%.
Velium
side effects and Toxicity
Symptoms of overdose include somnolence, confusion, coma, and diminished reflexes. Respiration, pulse and blood pressure should be monitored.
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Patient Information
Velium
Organisms Affected
Humans and other mammals