Pacitran
Brand names,
Pacitran
Analogs
Pacitran
Brand Names Mixture
Pacitran
Chemical_Formula
C16H13ClN2O
Pacitran
RX_link
http://www.rxlist.com/cgi/generic/diazepam.htm
Pacitran
fda sheet
Pacitran
msds (material safety sheet)
Pacitran
Synthesis Reference
Reeder, Sternbach; U.S. Pat. 3,371,085 (1968)
Pacitran
Molecular Weight
284.74 g/mol
Pacitran
Melting Point
125-126oC
Pacitran
H2O Solubility
Slightly soluble (50 mg/L)
Pacitran
State
solid
Pacitran
LogP
2.988
Pacitran
Dosage Forms
Tablets; Injectable solution
Pacitran
Indication
Used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome.
Pacitran
Pharmacology
Diazepam, a benzodiazepine, generates the same active metabolite as chlordiazepoxide and clorazepate. In animals, diazepam appears to act on parts of the limbic system, the thalamus and hypothalamus, and induces calming effects. Diazepam, unlike chlorpromazine and reserpine, has no demonstrable peripheral autonomic blocking action, nor does it produce extrapyramidal side effects; however, animals treated with diazepam do have a transient ataxia at higher doses. Diazepam was found to have transient cardiovascular depressor effects in dogs. Long-term experiments in rats revealed no disturbances of endocrine function. Injections into animals have produced localized irritation of tissue surrounding injection sites and some thickening of veins after intravenous use.
Pacitran
Absorption
Essentially complete, with a bioavailability of 93%.
Pacitran
side effects and Toxicity
Symptoms of overdose include somnolence, confusion, coma, and diminished reflexes. Respiration, pulse and blood pressure should be monitored.
Pacitran
Patient Information
Pacitran
Organisms Affected
Humans and other mammals