Ceregulart
Brand names,
Ceregulart
Analogs
Ceregulart
Brand Names Mixture
Ceregulart
Chemical_Formula
C16H13ClN2O
Ceregulart
RX_link
http://www.rxlist.com/cgi/generic/diazepam.htm
Ceregulart
fda sheet
Ceregulart
msds (material safety sheet)
Ceregulart
Synthesis Reference
Reeder, Sternbach; U.S. Pat. 3,371,085 (1968)
Ceregulart
Molecular Weight
284.74 g/mol
Ceregulart
Melting Point
125-126oC
Ceregulart
H2O Solubility
Slightly soluble (50 mg/L)
Ceregulart
State
solid
Ceregulart
LogP
2.988
Ceregulart
Dosage Forms
Tablets; Injectable solution
Ceregulart
Indication
Used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome.
Ceregulart
Pharmacology
Diazepam, a benzodiazepine, generates the same active metabolite as chlordiazepoxide and clorazepate. In animals, diazepam appears to act on parts of the limbic system, the thalamus and hypothalamus, and induces calming effects. Diazepam, unlike chlorpromazine and reserpine, has no demonstrable peripheral autonomic blocking action, nor does it produce extrapyramidal side effects; however, animals treated with diazepam do have a transient ataxia at higher doses. Diazepam was found to have transient cardiovascular depressor effects in dogs. Long-term experiments in rats revealed no disturbances of endocrine function. Injections into animals have produced localized irritation of tissue surrounding injection sites and some thickening of veins after intravenous use.
Ceregulart
Absorption
Essentially complete, with a bioavailability of 93%.
Ceregulart
side effects and Toxicity
Symptoms of overdose include somnolence, confusion, coma, and diminished reflexes. Respiration, pulse and blood pressure should be monitored.
Ceregulart
Patient Information
Ceregulart
Organisms Affected
Humans and other mammals