Sedipam
Brand names,
Sedipam
Analogs
Sedipam
Brand Names Mixture
Sedipam
Chemical_Formula
C16H13ClN2O
Sedipam
RX_link
http://www.rxlist.com/cgi/generic/diazepam.htm
Sedipam
fda sheet
Sedipam
msds (material safety sheet)
Sedipam
Synthesis Reference
Reeder, Sternbach; U.S. Pat. 3,371,085 (1968)
Sedipam
Molecular Weight
284.74 g/mol
Sedipam
Melting Point
125-126oC
Sedipam
H2O Solubility
Slightly soluble (50 mg/L)
Sedipam
State
solid
Sedipam
LogP
2.988
Sedipam
Dosage Forms
Tablets; Injectable solution
Sedipam
Indication
Used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome.
Sedipam
Pharmacology
Diazepam, a benzodiazepine, generates the same active metabolite as chlordiazepoxide and clorazepate. In animals, diazepam appears to act on parts of the limbic system, the thalamus and hypothalamus, and induces calming effects. Diazepam, unlike chlorpromazine and reserpine, has no demonstrable peripheral autonomic blocking action, nor does it produce extrapyramidal side effects; however, animals treated with diazepam do have a transient ataxia at higher doses. Diazepam was found to have transient cardiovascular depressor effects in dogs. Long-term experiments in rats revealed no disturbances of endocrine function. Injections into animals have produced localized irritation of tissue surrounding injection sites and some thickening of veins after intravenous use.
Sedipam
Absorption
Essentially complete, with a bioavailability of 93%.
Sedipam
side effects and Toxicity
Symptoms of overdose include somnolence, confusion, coma, and diminished reflexes. Respiration, pulse and blood pressure should be monitored.
Sedipam
Patient Information
Sedipam
Organisms Affected
Humans and other mammals