Dialar
Brand names,
Dialar
Analogs
Dialar
Brand Names Mixture
Dialar
Chemical_Formula
C16H13ClN2O
Dialar
RX_link
http://www.rxlist.com/cgi/generic/diazepam.htm
Dialar
fda sheet
Dialar
msds (material safety sheet)
Dialar
Synthesis Reference
Reeder, Sternbach; U.S. Pat. 3,371,085 (1968)
Dialar
Molecular Weight
284.74 g/mol
Dialar
Melting Point
125-126oC
Dialar
H2O Solubility
Slightly soluble (50 mg/L)
Dialar
State
solid
Dialar
LogP
2.988
Dialar
Dosage Forms
Tablets; Injectable solution
Dialar
Indication
Used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome.
Dialar
Pharmacology
Diazepam, a benzodiazepine, generates the same active metabolite as chlordiazepoxide and clorazepate. In animals, diazepam appears to act on parts of the limbic system, the thalamus and hypothalamus, and induces calming effects. Diazepam, unlike chlorpromazine and reserpine, has no demonstrable peripheral autonomic blocking action, nor does it produce extrapyramidal side effects; however, animals treated with diazepam do have a transient ataxia at higher doses. Diazepam was found to have transient cardiovascular depressor effects in dogs. Long-term experiments in rats revealed no disturbances of endocrine function. Injections into animals have produced localized irritation of tissue surrounding injection sites and some thickening of veins after intravenous use.
Dialar
Absorption
Essentially complete, with a bioavailability of 93%.
Dialar
side effects and Toxicity
Symptoms of overdose include somnolence, confusion, coma, and diminished reflexes. Respiration, pulse and blood pressure should be monitored.
Dialar
Patient Information
Dialar
Organisms Affected
Humans and other mammals