Domalium

Domalium Brand names, Domalium Analogs

Domalium Brand Names Mixture

No information avaliable

Domalium Chemical_Formula

C₁₆H₁₃ClN₂O

Domalium RX_link

http://www.rxlist.com/cgi/generic/diazepam.htm

Domalium fda sheet

Domalium msds (material safety sheet)

Domalium MSDS

Domalium Synthesis Reference

Reeder, Sternbach; U.S. Pat. 3,371,085 (1968)

Domalium Molecular Weight

284.74 g/mol

Domalium Melting Point

125-126^oC

Domalium H₂O Solubility

Slightly soluble (50 mg/L)

Domalium State

solid

Domalium LogP

2.988

Domalium Dosage Forms

Tablets; Injectable solution

Domalium Indication

Used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome.

Domalium Pharmacology

Diazepam, a benzodiazepine, generates the same active metabolite as chlordiazepoxide and clorazepate. In animals, diazepam appears to act on parts of the limbic system, the thalamus and hypothalamus, and induces calming effects. Diazepam, unlike chlorpromazine and reserpine, has no demonstrable peripheral autonomic blocking action, nor does it produce extrapyramidal side effects; however, animals treated with diazepam do have a transient ataxia at higher doses. Diazepam was found to have transient cardiovascular depressor effects in dogs. Long-term experiments in rats revealed no disturbances of endocrine function. Injections into animals have produced localized irritation of tissue surrounding injection sites and some thickening of veins after intravenous use.

Domalium Absorption

Essentially complete, with a bioavailability of 93%.

Domalium side effects and Toxicity

Symptoms of overdose include somnolence, confusion, coma, and diminished reflexes. Respiration, pulse and blood pressure should be monitored.

Domalium Patient Information

Domalium Organisms Affected

Humans and other mammals