Neurolytril
Brand names,
Neurolytril
Analogs
Neurolytril
Brand Names Mixture
Neurolytril
Chemical_Formula
C16H13ClN2O
Neurolytril
RX_link
http://www.rxlist.com/cgi/generic/diazepam.htm
Neurolytril
fda sheet
Neurolytril
msds (material safety sheet)
Neurolytril
Synthesis Reference
Reeder, Sternbach; U.S. Pat. 3,371,085 (1968)
Neurolytril
Molecular Weight
284.74 g/mol
Neurolytril
Melting Point
125-126oC
Neurolytril
H2O Solubility
Slightly soluble (50 mg/L)
Neurolytril
State
solid
Neurolytril
LogP
2.988
Neurolytril
Dosage Forms
Tablets; Injectable solution
Neurolytril
Indication
Used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome.
Neurolytril
Pharmacology
Diazepam, a benzodiazepine, generates the same active metabolite as chlordiazepoxide and clorazepate. In animals, diazepam appears to act on parts of the limbic system, the thalamus and hypothalamus, and induces calming effects. Diazepam, unlike chlorpromazine and reserpine, has no demonstrable peripheral autonomic blocking action, nor does it produce extrapyramidal side effects; however, animals treated with diazepam do have a transient ataxia at higher doses. Diazepam was found to have transient cardiovascular depressor effects in dogs. Long-term experiments in rats revealed no disturbances of endocrine function. Injections into animals have produced localized irritation of tissue surrounding injection sites and some thickening of veins after intravenous use.
Neurolytril
Absorption
Essentially complete, with a bioavailability of 93%.
Neurolytril
side effects and Toxicity
Symptoms of overdose include somnolence, confusion, coma, and diminished reflexes. Respiration, pulse and blood pressure should be monitored.
Neurolytril
Patient Information
Neurolytril
Organisms Affected
Humans and other mammals