Relanium
Brand names,
Relanium
Analogs
Relanium
Brand Names Mixture
Relanium
Chemical_Formula
C16H13ClN2O
Relanium
RX_link
http://www.rxlist.com/cgi/generic/diazepam.htm
Relanium
fda sheet
Relanium
msds (material safety sheet)
Relanium
Synthesis Reference
Reeder, Sternbach; U.S. Pat. 3,371,085 (1968)
Relanium
Molecular Weight
284.74 g/mol
Relanium
Melting Point
125-126oC
Relanium
H2O Solubility
Slightly soluble (50 mg/L)
Relanium
State
solid
Relanium
LogP
2.988
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Dosage Forms
Tablets; Injectable solution
Relanium
Indication
Used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome.
Relanium
Pharmacology
Diazepam, a benzodiazepine, generates the same active metabolite as chlordiazepoxide and clorazepate. In animals, diazepam appears to act on parts of the limbic system, the thalamus and hypothalamus, and induces calming effects. Diazepam, unlike chlorpromazine and reserpine, has no demonstrable peripheral autonomic blocking action, nor does it produce extrapyramidal side effects; however, animals treated with diazepam do have a transient ataxia at higher doses. Diazepam was found to have transient cardiovascular depressor effects in dogs. Long-term experiments in rats revealed no disturbances of endocrine function. Injections into animals have produced localized irritation of tissue surrounding injection sites and some thickening of veins after intravenous use.
Relanium
Absorption
Essentially complete, with a bioavailability of 93%.
Relanium
side effects and Toxicity
Symptoms of overdose include somnolence, confusion, coma, and diminished reflexes. Respiration, pulse and blood pressure should be monitored.
Relanium
Patient Information
Relanium
Organisms Affected
Humans and other mammals