Tensopam
Brand names,
Tensopam
Analogs
Tensopam
Brand Names Mixture
Tensopam
Chemical_Formula
C16H13ClN2O
Tensopam
RX_link
http://www.rxlist.com/cgi/generic/diazepam.htm
Tensopam
fda sheet
Tensopam
msds (material safety sheet)
Tensopam
Synthesis Reference
Reeder, Sternbach; U.S. Pat. 3,371,085 (1968)
Tensopam
Molecular Weight
284.74 g/mol
Tensopam
Melting Point
125-126oC
Tensopam
H2O Solubility
Slightly soluble (50 mg/L)
Tensopam
State
solid
Tensopam
LogP
2.988
Tensopam
Dosage Forms
Tablets; Injectable solution
Tensopam
Indication
Used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome.
Tensopam
Pharmacology
Diazepam, a benzodiazepine, generates the same active metabolite as chlordiazepoxide and clorazepate. In animals, diazepam appears to act on parts of the limbic system, the thalamus and hypothalamus, and induces calming effects. Diazepam, unlike chlorpromazine and reserpine, has no demonstrable peripheral autonomic blocking action, nor does it produce extrapyramidal side effects; however, animals treated with diazepam do have a transient ataxia at higher doses. Diazepam was found to have transient cardiovascular depressor effects in dogs. Long-term experiments in rats revealed no disturbances of endocrine function. Injections into animals have produced localized irritation of tissue surrounding injection sites and some thickening of veins after intravenous use.
Tensopam
Absorption
Essentially complete, with a bioavailability of 93%.
Tensopam
side effects and Toxicity
Symptoms of overdose include somnolence, confusion, coma, and diminished reflexes. Respiration, pulse and blood pressure should be monitored.
Tensopam
Patient Information
Tensopam
Organisms Affected
Humans and other mammals