Tranqdyn
Brand names,
Tranqdyn
Analogs
Tranqdyn
Brand Names Mixture
Tranqdyn
Chemical_Formula
C16H13ClN2O
Tranqdyn
RX_link
http://www.rxlist.com/cgi/generic/diazepam.htm
Tranqdyn
fda sheet
Tranqdyn
msds (material safety sheet)
Tranqdyn
Synthesis Reference
Reeder, Sternbach; U.S. Pat. 3,371,085 (1968)
Tranqdyn
Molecular Weight
284.74 g/mol
Tranqdyn
Melting Point
125-126oC
Tranqdyn
H2O Solubility
Slightly soluble (50 mg/L)
Tranqdyn
State
solid
Tranqdyn
LogP
2.988
Tranqdyn
Dosage Forms
Tablets; Injectable solution
Tranqdyn
Indication
Used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome.
Tranqdyn
Pharmacology
Diazepam, a benzodiazepine, generates the same active metabolite as chlordiazepoxide and clorazepate. In animals, diazepam appears to act on parts of the limbic system, the thalamus and hypothalamus, and induces calming effects. Diazepam, unlike chlorpromazine and reserpine, has no demonstrable peripheral autonomic blocking action, nor does it produce extrapyramidal side effects; however, animals treated with diazepam do have a transient ataxia at higher doses. Diazepam was found to have transient cardiovascular depressor effects in dogs. Long-term experiments in rats revealed no disturbances of endocrine function. Injections into animals have produced localized irritation of tissue surrounding injection sites and some thickening of veins after intravenous use.
Tranqdyn
Absorption
Essentially complete, with a bioavailability of 93%.
Tranqdyn
side effects and Toxicity
Symptoms of overdose include somnolence, confusion, coma, and diminished reflexes. Respiration, pulse and blood pressure should be monitored.
Tranqdyn
Patient Information
Tranqdyn
Organisms Affected
Humans and other mammals