Renborin
Brand names,
Renborin
Analogs
Renborin
Brand Names Mixture
Renborin
Chemical_Formula
C16H13ClN2O
Renborin
RX_link
http://www.rxlist.com/cgi/generic/diazepam.htm
Renborin
fda sheet
Renborin
msds (material safety sheet)
Renborin
Synthesis Reference
Reeder, Sternbach; U.S. Pat. 3,371,085 (1968)
Renborin
Molecular Weight
284.74 g/mol
Renborin
Melting Point
125-126oC
Renborin
H2O Solubility
Slightly soluble (50 mg/L)
Renborin
State
solid
Renborin
LogP
2.988
Renborin
Dosage Forms
Tablets; Injectable solution
Renborin
Indication
Used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome.
Renborin
Pharmacology
Diazepam, a benzodiazepine, generates the same active metabolite as chlordiazepoxide and clorazepate. In animals, diazepam appears to act on parts of the limbic system, the thalamus and hypothalamus, and induces calming effects. Diazepam, unlike chlorpromazine and reserpine, has no demonstrable peripheral autonomic blocking action, nor does it produce extrapyramidal side effects; however, animals treated with diazepam do have a transient ataxia at higher doses. Diazepam was found to have transient cardiovascular depressor effects in dogs. Long-term experiments in rats revealed no disturbances of endocrine function. Injections into animals have produced localized irritation of tissue surrounding injection sites and some thickening of veins after intravenous use.
Renborin
Absorption
Essentially complete, with a bioavailability of 93%.
Renborin
side effects and Toxicity
Symptoms of overdose include somnolence, confusion, coma, and diminished reflexes. Respiration, pulse and blood pressure should be monitored.
Renborin
Patient Information
Renborin
Organisms Affected
Humans and other mammals