Diazepam Intensol
Brand names,
Diazepam Intensol
Analogs
Diazepam Intensol
Brand Names Mixture
Diazepam Intensol
Chemical_Formula
C16H13ClN2O
Diazepam Intensol
RX_link
http://www.rxlist.com/cgi/generic/diazepam.htm
Diazepam Intensol
fda sheet
Diazepam Intensol
msds (material safety sheet)
Diazepam Intensol
Synthesis Reference
Reeder, Sternbach; U.S. Pat. 3,371,085 (1968)
Diazepam Intensol
Molecular Weight
284.74 g/mol
Diazepam Intensol
Melting Point
125-126oC
Diazepam Intensol
H2O Solubility
Slightly soluble (50 mg/L)
Diazepam Intensol
State
solid
Diazepam Intensol
LogP
2.988
Diazepam Intensol
Dosage Forms
Tablets; Injectable solution
Diazepam Intensol
Indication
Used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome.
Diazepam Intensol
Pharmacology
Diazepam, a benzodiazepine, generates the same active metabolite as chlordiazepoxide and clorazepate. In animals, diazepam appears to act on parts of the limbic system, the thalamus and hypothalamus, and induces calming effects. Diazepam, unlike chlorpromazine and reserpine, has no demonstrable peripheral autonomic blocking action, nor does it produce extrapyramidal side effects; however, animals treated with diazepam do have a transient ataxia at higher doses. Diazepam was found to have transient cardiovascular depressor effects in dogs. Long-term experiments in rats revealed no disturbances of endocrine function. Injections into animals have produced localized irritation of tissue surrounding injection sites and some thickening of veins after intravenous use.
Diazepam Intensol
Absorption
Essentially complete, with a bioavailability of 93%.
Diazepam Intensol
side effects and Toxicity
Symptoms of overdose include somnolence, confusion, coma, and diminished reflexes. Respiration, pulse and blood pressure should be monitored.
Diazepam Intensol
Patient Information
Diazepam Intensol
Organisms Affected
Humans and other mammals