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Zipan Brand names, Zipan Analogs

Zipan Brand Names Mixture

  • Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)

Zipan Chemical_Formula


Zipan RX_link

Zipan fda sheet

Zipan FDA

Zipan msds (material safety sheet)

Zipan Synthesis Reference

Charpentier, U.S. Pat. 2,503,451 (1950)

Zipan Molecular Weight

284.42 g/mol

Zipan Melting Point


Zipan H2O Solubility

Freely soluble

Zipan State


Zipan LogP


Zipan Dosage Forms

Tablet; Suppository; Opthalmic drops; Syrup

Zipan Indication

For the treatment of allergic disorders, itching, nausea and vomiting.

Zipan Pharmacology

Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.

Zipan Absorption

On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.

Zipan side effects and Toxicity

Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)

Zipan Patient Information

Zipan Organisms Affected

Humans and other mammals