Serenzin
Brand names,
Serenzin
Analogs
Serenzin
Brand Names Mixture
Serenzin
Chemical_Formula
C16H13ClN2O
Serenzin
RX_link
http://www.rxlist.com/cgi/generic/diazepam.htm
Serenzin
fda sheet
Serenzin
msds (material safety sheet)
Serenzin
Synthesis Reference
Reeder, Sternbach; U.S. Pat. 3,371,085 (1968)
Serenzin
Molecular Weight
284.74 g/mol
Serenzin
Melting Point
125-126oC
Serenzin
H2O Solubility
Slightly soluble (50 mg/L)
Serenzin
State
solid
Serenzin
LogP
2.988
Serenzin
Dosage Forms
Tablets; Injectable solution
Serenzin
Indication
Used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome.
Serenzin
Pharmacology
Diazepam, a benzodiazepine, generates the same active metabolite as chlordiazepoxide and clorazepate. In animals, diazepam appears to act on parts of the limbic system, the thalamus and hypothalamus, and induces calming effects. Diazepam, unlike chlorpromazine and reserpine, has no demonstrable peripheral autonomic blocking action, nor does it produce extrapyramidal side effects; however, animals treated with diazepam do have a transient ataxia at higher doses. Diazepam was found to have transient cardiovascular depressor effects in dogs. Long-term experiments in rats revealed no disturbances of endocrine function. Injections into animals have produced localized irritation of tissue surrounding injection sites and some thickening of veins after intravenous use.
Serenzin
Absorption
Essentially complete, with a bioavailability of 93%.
Serenzin
side effects and Toxicity
Symptoms of overdose include somnolence, confusion, coma, and diminished reflexes. Respiration, pulse and blood pressure should be monitored.
Serenzin
Patient Information
Serenzin
Organisms Affected
Humans and other mammals