Paxel

Paxel Brand names, Paxel Analogs

Paxel Brand Names Mixture

No information avaliable

Paxel Chemical_Formula

C₁₆H₁₃ClN₂O

Paxel RX_link

http://www.rxlist.com/cgi/generic/diazepam.htm

Paxel fda sheet

Paxel msds (material safety sheet)

Paxel MSDS

Paxel Synthesis Reference

Reeder, Sternbach; U.S. Pat. 3,371,085 (1968)

Paxel Molecular Weight

284.74 g/mol

Paxel Melting Point

125-126^oC

Paxel H₂O Solubility

Slightly soluble (50 mg/L)

Paxel State

solid

Paxel LogP

2.988

Paxel Dosage Forms

Tablets; Injectable solution

Paxel Indication

Used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome.

Paxel Pharmacology

Diazepam, a benzodiazepine, generates the same active metabolite as chlordiazepoxide and clorazepate. In animals, diazepam appears to act on parts of the limbic system, the thalamus and hypothalamus, and induces calming effects. Diazepam, unlike chlorpromazine and reserpine, has no demonstrable peripheral autonomic blocking action, nor does it produce extrapyramidal side effects; however, animals treated with diazepam do have a transient ataxia at higher doses. Diazepam was found to have transient cardiovascular depressor effects in dogs. Long-term experiments in rats revealed no disturbances of endocrine function. Injections into animals have produced localized irritation of tissue surrounding injection sites and some thickening of veins after intravenous use.

Paxel Absorption

Essentially complete, with a bioavailability of 93%.

Paxel side effects and Toxicity

Symptoms of overdose include somnolence, confusion, coma, and diminished reflexes. Respiration, pulse and blood pressure should be monitored.

Paxel Patient Information

Paxel Organisms Affected

Humans and other mammals