Relaminal
Brand names,
Relaminal
Analogs
Relaminal
Brand Names Mixture
Relaminal
Chemical_Formula
C16H13ClN2O
Relaminal
RX_link
http://www.rxlist.com/cgi/generic/diazepam.htm
Relaminal
fda sheet
Relaminal
msds (material safety sheet)
Relaminal
Synthesis Reference
Reeder, Sternbach; U.S. Pat. 3,371,085 (1968)
Relaminal
Molecular Weight
284.74 g/mol
Relaminal
Melting Point
125-126oC
Relaminal
H2O Solubility
Slightly soluble (50 mg/L)
Relaminal
State
solid
Relaminal
LogP
2.988
Relaminal
Dosage Forms
Tablets; Injectable solution
Relaminal
Indication
Used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome.
Relaminal
Pharmacology
Diazepam, a benzodiazepine, generates the same active metabolite as chlordiazepoxide and clorazepate. In animals, diazepam appears to act on parts of the limbic system, the thalamus and hypothalamus, and induces calming effects. Diazepam, unlike chlorpromazine and reserpine, has no demonstrable peripheral autonomic blocking action, nor does it produce extrapyramidal side effects; however, animals treated with diazepam do have a transient ataxia at higher doses. Diazepam was found to have transient cardiovascular depressor effects in dogs. Long-term experiments in rats revealed no disturbances of endocrine function. Injections into animals have produced localized irritation of tissue surrounding injection sites and some thickening of veins after intravenous use.
Relaminal
Absorption
Essentially complete, with a bioavailability of 93%.
Relaminal
side effects and Toxicity
Symptoms of overdose include somnolence, confusion, coma, and diminished reflexes. Respiration, pulse and blood pressure should be monitored.
Relaminal
Patient Information
Relaminal
Organisms Affected
Humans and other mammals