Novo-Dipam
Brand names,
Novo-Dipam
Analogs
Novo-Dipam
Brand Names Mixture
Novo-Dipam
Chemical_Formula
C16H13ClN2O
Novo-Dipam
RX_link
http://www.rxlist.com/cgi/generic/diazepam.htm
Novo-Dipam
fda sheet
Novo-Dipam
msds (material safety sheet)
Novo-Dipam
Synthesis Reference
Reeder, Sternbach; U.S. Pat. 3,371,085 (1968)
Novo-Dipam
Molecular Weight
284.74 g/mol
Novo-Dipam
Melting Point
125-126oC
Novo-Dipam
H2O Solubility
Slightly soluble (50 mg/L)
Novo-Dipam
State
solid
Novo-Dipam
LogP
2.988
Novo-Dipam
Dosage Forms
Tablets; Injectable solution
Novo-Dipam
Indication
Used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome.
Novo-Dipam
Pharmacology
Diazepam, a benzodiazepine, generates the same active metabolite as chlordiazepoxide and clorazepate. In animals, diazepam appears to act on parts of the limbic system, the thalamus and hypothalamus, and induces calming effects. Diazepam, unlike chlorpromazine and reserpine, has no demonstrable peripheral autonomic blocking action, nor does it produce extrapyramidal side effects; however, animals treated with diazepam do have a transient ataxia at higher doses. Diazepam was found to have transient cardiovascular depressor effects in dogs. Long-term experiments in rats revealed no disturbances of endocrine function. Injections into animals have produced localized irritation of tissue surrounding injection sites and some thickening of veins after intravenous use.
Novo-Dipam
Absorption
Essentially complete, with a bioavailability of 93%.
Novo-Dipam
side effects and Toxicity
Symptoms of overdose include somnolence, confusion, coma, and diminished reflexes. Respiration, pulse and blood pressure should be monitored.
Novo-Dipam
Patient Information
Novo-Dipam
Organisms Affected
Humans and other mammals