Usempax Ap
Brand names,
Usempax Ap
Analogs
Usempax Ap
Brand Names Mixture
Usempax Ap
Chemical_Formula
C16H13ClN2O
Usempax Ap
RX_link
http://www.rxlist.com/cgi/generic/diazepam.htm
Usempax Ap
fda sheet
Usempax Ap
msds (material safety sheet)
Usempax Ap
Synthesis Reference
Reeder, Sternbach; U.S. Pat. 3,371,085 (1968)
Usempax Ap
Molecular Weight
284.74 g/mol
Usempax Ap
Melting Point
125-126oC
Usempax Ap
H2O Solubility
Slightly soluble (50 mg/L)
Usempax Ap
State
solid
Usempax Ap
LogP
2.988
Usempax Ap
Dosage Forms
Tablets; Injectable solution
Usempax Ap
Indication
Used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome.
Usempax Ap
Pharmacology
Diazepam, a benzodiazepine, generates the same active metabolite as chlordiazepoxide and clorazepate. In animals, diazepam appears to act on parts of the limbic system, the thalamus and hypothalamus, and induces calming effects. Diazepam, unlike chlorpromazine and reserpine, has no demonstrable peripheral autonomic blocking action, nor does it produce extrapyramidal side effects; however, animals treated with diazepam do have a transient ataxia at higher doses. Diazepam was found to have transient cardiovascular depressor effects in dogs. Long-term experiments in rats revealed no disturbances of endocrine function. Injections into animals have produced localized irritation of tissue surrounding injection sites and some thickening of veins after intravenous use.
Usempax Ap
Absorption
Essentially complete, with a bioavailability of 93%.
Usempax Ap
side effects and Toxicity
Symptoms of overdose include somnolence, confusion, coma, and diminished reflexes. Respiration, pulse and blood pressure should be monitored.
Usempax Ap
Patient Information
Usempax Ap
Organisms Affected
Humans and other mammals