Ansiolin
Brand names,
Ansiolin
Analogs
Ansiolin
Brand Names Mixture
Ansiolin
Chemical_Formula
C16H13ClN2O
Ansiolin
RX_link
http://www.rxlist.com/cgi/generic/diazepam.htm
Ansiolin
fda sheet
Ansiolin
msds (material safety sheet)
Ansiolin
Synthesis Reference
Reeder, Sternbach; U.S. Pat. 3,371,085 (1968)
Ansiolin
Molecular Weight
284.74 g/mol
Ansiolin
Melting Point
125-126oC
Ansiolin
H2O Solubility
Slightly soluble (50 mg/L)
Ansiolin
State
solid
Ansiolin
LogP
2.988
Ansiolin
Dosage Forms
Tablets; Injectable solution
Ansiolin
Indication
Used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome.
Ansiolin
Pharmacology
Diazepam, a benzodiazepine, generates the same active metabolite as chlordiazepoxide and clorazepate. In animals, diazepam appears to act on parts of the limbic system, the thalamus and hypothalamus, and induces calming effects. Diazepam, unlike chlorpromazine and reserpine, has no demonstrable peripheral autonomic blocking action, nor does it produce extrapyramidal side effects; however, animals treated with diazepam do have a transient ataxia at higher doses. Diazepam was found to have transient cardiovascular depressor effects in dogs. Long-term experiments in rats revealed no disturbances of endocrine function. Injections into animals have produced localized irritation of tissue surrounding injection sites and some thickening of veins after intravenous use.
Ansiolin
Absorption
Essentially complete, with a bioavailability of 93%.
Ansiolin
side effects and Toxicity
Symptoms of overdose include somnolence, confusion, coma, and diminished reflexes. Respiration, pulse and blood pressure should be monitored.
Ansiolin
Patient Information
Ansiolin
Organisms Affected
Humans and other mammals