Kabivitrum
Brand names,
Kabivitrum
Analogs
Kabivitrum
Brand Names Mixture
Kabivitrum
Chemical_Formula
C16H13ClN2O
Kabivitrum
RX_link
http://www.rxlist.com/cgi/generic/diazepam.htm
Kabivitrum
fda sheet
Kabivitrum
msds (material safety sheet)
Kabivitrum
Synthesis Reference
Reeder, Sternbach; U.S. Pat. 3,371,085 (1968)
Kabivitrum
Molecular Weight
284.74 g/mol
Kabivitrum
Melting Point
125-126oC
Kabivitrum
H2O Solubility
Slightly soluble (50 mg/L)
Kabivitrum
State
solid
Kabivitrum
LogP
2.988
Kabivitrum
Dosage Forms
Tablets; Injectable solution
Kabivitrum
Indication
Used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome.
Kabivitrum
Pharmacology
Diazepam, a benzodiazepine, generates the same active metabolite as chlordiazepoxide and clorazepate. In animals, diazepam appears to act on parts of the limbic system, the thalamus and hypothalamus, and induces calming effects. Diazepam, unlike chlorpromazine and reserpine, has no demonstrable peripheral autonomic blocking action, nor does it produce extrapyramidal side effects; however, animals treated with diazepam do have a transient ataxia at higher doses. Diazepam was found to have transient cardiovascular depressor effects in dogs. Long-term experiments in rats revealed no disturbances of endocrine function. Injections into animals have produced localized irritation of tissue surrounding injection sites and some thickening of veins after intravenous use.
Kabivitrum
Absorption
Essentially complete, with a bioavailability of 93%.
Kabivitrum
side effects and Toxicity
Symptoms of overdose include somnolence, confusion, coma, and diminished reflexes. Respiration, pulse and blood pressure should be monitored.
Kabivitrum
Patient Information
Kabivitrum
Organisms Affected
Humans and other mammals