Diazemulus
Brand names,
Diazemulus
Analogs
Diazemulus
Brand Names Mixture
Diazemulus
Chemical_Formula
C16H13ClN2O
Diazemulus
RX_link
http://www.rxlist.com/cgi/generic/diazepam.htm
Diazemulus
fda sheet
Diazemulus
msds (material safety sheet)
Diazemulus
Synthesis Reference
Reeder, Sternbach; U.S. Pat. 3,371,085 (1968)
Diazemulus
Molecular Weight
284.74 g/mol
Diazemulus
Melting Point
125-126oC
Diazemulus
H2O Solubility
Slightly soluble (50 mg/L)
Diazemulus
State
solid
Diazemulus
LogP
2.988
Diazemulus
Dosage Forms
Tablets; Injectable solution
Diazemulus
Indication
Used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome.
Diazemulus
Pharmacology
Diazepam, a benzodiazepine, generates the same active metabolite as chlordiazepoxide and clorazepate. In animals, diazepam appears to act on parts of the limbic system, the thalamus and hypothalamus, and induces calming effects. Diazepam, unlike chlorpromazine and reserpine, has no demonstrable peripheral autonomic blocking action, nor does it produce extrapyramidal side effects; however, animals treated with diazepam do have a transient ataxia at higher doses. Diazepam was found to have transient cardiovascular depressor effects in dogs. Long-term experiments in rats revealed no disturbances of endocrine function. Injections into animals have produced localized irritation of tissue surrounding injection sites and some thickening of veins after intravenous use.
Diazemulus
Absorption
Essentially complete, with a bioavailability of 93%.
Diazemulus
side effects and Toxicity
Symptoms of overdose include somnolence, confusion, coma, and diminished reflexes. Respiration, pulse and blood pressure should be monitored.
Diazemulus
Patient Information
Diazemulus
Organisms Affected
Humans and other mammals