Serenamin
Brand names,
Serenamin
Analogs
Serenamin
Brand Names Mixture
Serenamin
Chemical_Formula
C16H13ClN2O
Serenamin
RX_link
http://www.rxlist.com/cgi/generic/diazepam.htm
Serenamin
fda sheet
Serenamin
msds (material safety sheet)
Serenamin
Synthesis Reference
Reeder, Sternbach; U.S. Pat. 3,371,085 (1968)
Serenamin
Molecular Weight
284.74 g/mol
Serenamin
Melting Point
125-126oC
Serenamin
H2O Solubility
Slightly soluble (50 mg/L)
Serenamin
State
solid
Serenamin
LogP
2.988
Serenamin
Dosage Forms
Tablets; Injectable solution
Serenamin
Indication
Used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome.
Serenamin
Pharmacology
Diazepam, a benzodiazepine, generates the same active metabolite as chlordiazepoxide and clorazepate. In animals, diazepam appears to act on parts of the limbic system, the thalamus and hypothalamus, and induces calming effects. Diazepam, unlike chlorpromazine and reserpine, has no demonstrable peripheral autonomic blocking action, nor does it produce extrapyramidal side effects; however, animals treated with diazepam do have a transient ataxia at higher doses. Diazepam was found to have transient cardiovascular depressor effects in dogs. Long-term experiments in rats revealed no disturbances of endocrine function. Injections into animals have produced localized irritation of tissue surrounding injection sites and some thickening of veins after intravenous use.
Serenamin
Absorption
Essentially complete, with a bioavailability of 93%.
Serenamin
side effects and Toxicity
Symptoms of overdose include somnolence, confusion, coma, and diminished reflexes. Respiration, pulse and blood pressure should be monitored.
Serenamin
Patient Information
Serenamin
Organisms Affected
Humans and other mammals