Diazepan
Brand names,
Diazepan
Analogs
Diazepan
Brand Names Mixture
Diazepan
Chemical_Formula
C16H13ClN2O
Diazepan
RX_link
http://www.rxlist.com/cgi/generic/diazepam.htm
Diazepan
fda sheet
Diazepan
msds (material safety sheet)
Diazepan
Synthesis Reference
Reeder, Sternbach; U.S. Pat. 3,371,085 (1968)
Diazepan
Molecular Weight
284.74 g/mol
Diazepan
Melting Point
125-126oC
Diazepan
H2O Solubility
Slightly soluble (50 mg/L)
Diazepan
State
solid
Diazepan
LogP
2.988
Diazepan
Dosage Forms
Tablets; Injectable solution
Diazepan
Indication
Used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome.
Diazepan
Pharmacology
Diazepam, a benzodiazepine, generates the same active metabolite as chlordiazepoxide and clorazepate. In animals, diazepam appears to act on parts of the limbic system, the thalamus and hypothalamus, and induces calming effects. Diazepam, unlike chlorpromazine and reserpine, has no demonstrable peripheral autonomic blocking action, nor does it produce extrapyramidal side effects; however, animals treated with diazepam do have a transient ataxia at higher doses. Diazepam was found to have transient cardiovascular depressor effects in dogs. Long-term experiments in rats revealed no disturbances of endocrine function. Injections into animals have produced localized irritation of tissue surrounding injection sites and some thickening of veins after intravenous use.
Diazepan
Absorption
Essentially complete, with a bioavailability of 93%.
Diazepan
side effects and Toxicity
Symptoms of overdose include somnolence, confusion, coma, and diminished reflexes. Respiration, pulse and blood pressure should be monitored.
Diazepan
Patient Information
Diazepan
Organisms Affected
Humans and other mammals