Dienpax
Brand names,
Dienpax
Analogs
Dienpax
Brand Names Mixture
Dienpax
Chemical_Formula
C16H13ClN2O
Dienpax
RX_link
http://www.rxlist.com/cgi/generic/diazepam.htm
Dienpax
fda sheet
Dienpax
msds (material safety sheet)
Dienpax
Synthesis Reference
Reeder, Sternbach; U.S. Pat. 3,371,085 (1968)
Dienpax
Molecular Weight
284.74 g/mol
Dienpax
Melting Point
125-126oC
Dienpax
H2O Solubility
Slightly soluble (50 mg/L)
Dienpax
State
solid
Dienpax
LogP
2.988
Dienpax
Dosage Forms
Tablets; Injectable solution
Dienpax
Indication
Used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome.
Dienpax
Pharmacology
Diazepam, a benzodiazepine, generates the same active metabolite as chlordiazepoxide and clorazepate. In animals, diazepam appears to act on parts of the limbic system, the thalamus and hypothalamus, and induces calming effects. Diazepam, unlike chlorpromazine and reserpine, has no demonstrable peripheral autonomic blocking action, nor does it produce extrapyramidal side effects; however, animals treated with diazepam do have a transient ataxia at higher doses. Diazepam was found to have transient cardiovascular depressor effects in dogs. Long-term experiments in rats revealed no disturbances of endocrine function. Injections into animals have produced localized irritation of tissue surrounding injection sites and some thickening of veins after intravenous use.
Dienpax
Absorption
Essentially complete, with a bioavailability of 93%.
Dienpax
side effects and Toxicity
Symptoms of overdose include somnolence, confusion, coma, and diminished reflexes. Respiration, pulse and blood pressure should be monitored.
Dienpax
Patient Information
Dienpax
Organisms Affected
Humans and other mammals