Alboral
Brand names,
Alboral
Analogs
Alboral
Brand Names Mixture
Alboral
Chemical_Formula
C16H13ClN2O
Alboral
RX_link
http://www.rxlist.com/cgi/generic/diazepam.htm
Alboral
fda sheet
Alboral
msds (material safety sheet)
Alboral
Synthesis Reference
Reeder, Sternbach; U.S. Pat. 3,371,085 (1968)
Alboral
Molecular Weight
284.74 g/mol
Alboral
Melting Point
125-126oC
Alboral
H2O Solubility
Slightly soluble (50 mg/L)
Alboral
State
solid
Alboral
LogP
2.988
Alboral
Dosage Forms
Tablets; Injectable solution
Alboral
Indication
Used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome.
Alboral
Pharmacology
Diazepam, a benzodiazepine, generates the same active metabolite as chlordiazepoxide and clorazepate. In animals, diazepam appears to act on parts of the limbic system, the thalamus and hypothalamus, and induces calming effects. Diazepam, unlike chlorpromazine and reserpine, has no demonstrable peripheral autonomic blocking action, nor does it produce extrapyramidal side effects; however, animals treated with diazepam do have a transient ataxia at higher doses. Diazepam was found to have transient cardiovascular depressor effects in dogs. Long-term experiments in rats revealed no disturbances of endocrine function. Injections into animals have produced localized irritation of tissue surrounding injection sites and some thickening of veins after intravenous use.
Alboral
Absorption
Essentially complete, with a bioavailability of 93%.
Alboral
side effects and Toxicity
Symptoms of overdose include somnolence, confusion, coma, and diminished reflexes. Respiration, pulse and blood pressure should be monitored.
Alboral
Patient Information
Alboral
Organisms Affected
Humans and other mammals