Stesolin
Brand names,
Stesolin
Analogs
Stesolin
Brand Names Mixture
Stesolin
Chemical_Formula
C16H13ClN2O
Stesolin
RX_link
http://www.rxlist.com/cgi/generic/diazepam.htm
Stesolin
fda sheet
Stesolin
msds (material safety sheet)
Stesolin
Synthesis Reference
Reeder, Sternbach; U.S. Pat. 3,371,085 (1968)
Stesolin
Molecular Weight
284.74 g/mol
Stesolin
Melting Point
125-126oC
Stesolin
H2O Solubility
Slightly soluble (50 mg/L)
Stesolin
State
solid
Stesolin
LogP
2.988
Stesolin
Dosage Forms
Tablets; Injectable solution
Stesolin
Indication
Used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome.
Stesolin
Pharmacology
Diazepam, a benzodiazepine, generates the same active metabolite as chlordiazepoxide and clorazepate. In animals, diazepam appears to act on parts of the limbic system, the thalamus and hypothalamus, and induces calming effects. Diazepam, unlike chlorpromazine and reserpine, has no demonstrable peripheral autonomic blocking action, nor does it produce extrapyramidal side effects; however, animals treated with diazepam do have a transient ataxia at higher doses. Diazepam was found to have transient cardiovascular depressor effects in dogs. Long-term experiments in rats revealed no disturbances of endocrine function. Injections into animals have produced localized irritation of tissue surrounding injection sites and some thickening of veins after intravenous use.
Stesolin
Absorption
Essentially complete, with a bioavailability of 93%.
Stesolin
side effects and Toxicity
Symptoms of overdose include somnolence, confusion, coma, and diminished reflexes. Respiration, pulse and blood pressure should be monitored.
Stesolin
Patient Information
Stesolin
Organisms Affected
Humans and other mammals