Plidan

Plidan Brand names, Plidan Analogs

Plidan Brand Names Mixture

No information avaliable

Plidan Chemical_Formula

C₁₆H₁₃ClN₂O

Plidan RX_link

http://www.rxlist.com/cgi/generic/diazepam.htm

Plidan fda sheet

Plidan msds (material safety sheet)

Plidan MSDS

Plidan Synthesis Reference

Reeder, Sternbach; U.S. Pat. 3,371,085 (1968)

Plidan Molecular Weight

284.74 g/mol

Plidan Melting Point

125-126^oC

Plidan H₂O Solubility

Slightly soluble (50 mg/L)

Plidan State

solid

Plidan LogP

2.988

Plidan Dosage Forms

Tablets; Injectable solution

Plidan Indication

Used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome.

Plidan Pharmacology

Diazepam, a benzodiazepine, generates the same active metabolite as chlordiazepoxide and clorazepate. In animals, diazepam appears to act on parts of the limbic system, the thalamus and hypothalamus, and induces calming effects. Diazepam, unlike chlorpromazine and reserpine, has no demonstrable peripheral autonomic blocking action, nor does it produce extrapyramidal side effects; however, animals treated with diazepam do have a transient ataxia at higher doses. Diazepam was found to have transient cardiovascular depressor effects in dogs. Long-term experiments in rats revealed no disturbances of endocrine function. Injections into animals have produced localized irritation of tissue surrounding injection sites and some thickening of veins after intravenous use.

Plidan Absorption

Essentially complete, with a bioavailability of 93%.

Plidan side effects and Toxicity

Symptoms of overdose include somnolence, confusion, coma, and diminished reflexes. Respiration, pulse and blood pressure should be monitored.

Plidan Patient Information

Plidan Organisms Affected

Humans and other mammals