Diapam

Diapam Brand names, Diapam Analogs

Diapam Brand Names Mixture

No information avaliable

Diapam Chemical_Formula

C₁₆H₁₃ClN₂O

Diapam RX_link

http://www.rxlist.com/cgi/generic/diazepam.htm

Diapam fda sheet

Diapam msds (material safety sheet)

Diapam MSDS

Diapam Synthesis Reference

Reeder, Sternbach; U.S. Pat. 3,371,085 (1968)

Diapam Molecular Weight

284.74 g/mol

Diapam Melting Point

125-126^oC

Diapam H₂O Solubility

Slightly soluble (50 mg/L)

Diapam State

solid

Diapam LogP

2.988

Diapam Dosage Forms

Tablets; Injectable solution

Diapam Indication

Used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome.

Diapam Pharmacology

Diazepam, a benzodiazepine, generates the same active metabolite as chlordiazepoxide and clorazepate. In animals, diazepam appears to act on parts of the limbic system, the thalamus and hypothalamus, and induces calming effects. Diazepam, unlike chlorpromazine and reserpine, has no demonstrable peripheral autonomic blocking action, nor does it produce extrapyramidal side effects; however, animals treated with diazepam do have a transient ataxia at higher doses. Diazepam was found to have transient cardiovascular depressor effects in dogs. Long-term experiments in rats revealed no disturbances of endocrine function. Injections into animals have produced localized irritation of tissue surrounding injection sites and some thickening of veins after intravenous use.

Diapam Absorption

Essentially complete, with a bioavailability of 93%.

Diapam side effects and Toxicity

Symptoms of overdose include somnolence, confusion, coma, and diminished reflexes. Respiration, pulse and blood pressure should be monitored.

Diapam Patient Information

Diapam Organisms Affected

Humans and other mammals