Servizepam
Brand names,
Servizepam
Analogs
Servizepam
Brand Names Mixture
Servizepam
Chemical_Formula
C16H13ClN2O
Servizepam
RX_link
http://www.rxlist.com/cgi/generic/diazepam.htm
Servizepam
fda sheet
Servizepam
msds (material safety sheet)
Servizepam
Synthesis Reference
Reeder, Sternbach; U.S. Pat. 3,371,085 (1968)
Servizepam
Molecular Weight
284.74 g/mol
Servizepam
Melting Point
125-126oC
Servizepam
H2O Solubility
Slightly soluble (50 mg/L)
Servizepam
State
solid
Servizepam
LogP
2.988
Servizepam
Dosage Forms
Tablets; Injectable solution
Servizepam
Indication
Used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome.
Servizepam
Pharmacology
Diazepam, a benzodiazepine, generates the same active metabolite as chlordiazepoxide and clorazepate. In animals, diazepam appears to act on parts of the limbic system, the thalamus and hypothalamus, and induces calming effects. Diazepam, unlike chlorpromazine and reserpine, has no demonstrable peripheral autonomic blocking action, nor does it produce extrapyramidal side effects; however, animals treated with diazepam do have a transient ataxia at higher doses. Diazepam was found to have transient cardiovascular depressor effects in dogs. Long-term experiments in rats revealed no disturbances of endocrine function. Injections into animals have produced localized irritation of tissue surrounding injection sites and some thickening of veins after intravenous use.
Servizepam
Absorption
Essentially complete, with a bioavailability of 93%.
Servizepam
side effects and Toxicity
Symptoms of overdose include somnolence, confusion, coma, and diminished reflexes. Respiration, pulse and blood pressure should be monitored.
Servizepam
Patient Information
Servizepam
Organisms Affected
Humans and other mammals