Umbrium
Brand names,
Umbrium
Analogs
Umbrium
Brand Names Mixture
Umbrium
Chemical_Formula
C16H13ClN2O
Umbrium
RX_link
http://www.rxlist.com/cgi/generic/diazepam.htm
Umbrium
fda sheet
Umbrium
msds (material safety sheet)
Umbrium
Synthesis Reference
Reeder, Sternbach; U.S. Pat. 3,371,085 (1968)
Umbrium
Molecular Weight
284.74 g/mol
Umbrium
Melting Point
125-126oC
Umbrium
H2O Solubility
Slightly soluble (50 mg/L)
Umbrium
State
solid
Umbrium
LogP
2.988
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Dosage Forms
Tablets; Injectable solution
Umbrium
Indication
Used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome.
Umbrium
Pharmacology
Diazepam, a benzodiazepine, generates the same active metabolite as chlordiazepoxide and clorazepate. In animals, diazepam appears to act on parts of the limbic system, the thalamus and hypothalamus, and induces calming effects. Diazepam, unlike chlorpromazine and reserpine, has no demonstrable peripheral autonomic blocking action, nor does it produce extrapyramidal side effects; however, animals treated with diazepam do have a transient ataxia at higher doses. Diazepam was found to have transient cardiovascular depressor effects in dogs. Long-term experiments in rats revealed no disturbances of endocrine function. Injections into animals have produced localized irritation of tissue surrounding injection sites and some thickening of veins after intravenous use.
Umbrium
Absorption
Essentially complete, with a bioavailability of 93%.
Umbrium
side effects and Toxicity
Symptoms of overdose include somnolence, confusion, coma, and diminished reflexes. Respiration, pulse and blood pressure should be monitored.
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Patient Information
Umbrium
Organisms Affected
Humans and other mammals