Valrelease
Brand names,
Valrelease
Analogs
Valrelease
Brand Names Mixture
Valrelease
Chemical_Formula
C16H13ClN2O
Valrelease
RX_link
http://www.rxlist.com/cgi/generic/diazepam.htm
Valrelease
fda sheet
Valrelease
msds (material safety sheet)
Valrelease
Synthesis Reference
Reeder, Sternbach; U.S. Pat. 3,371,085 (1968)
Valrelease
Molecular Weight
284.74 g/mol
Valrelease
Melting Point
125-126oC
Valrelease
H2O Solubility
Slightly soluble (50 mg/L)
Valrelease
State
solid
Valrelease
LogP
2.988
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Dosage Forms
Tablets; Injectable solution
Valrelease
Indication
Used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome.
Valrelease
Pharmacology
Diazepam, a benzodiazepine, generates the same active metabolite as chlordiazepoxide and clorazepate. In animals, diazepam appears to act on parts of the limbic system, the thalamus and hypothalamus, and induces calming effects. Diazepam, unlike chlorpromazine and reserpine, has no demonstrable peripheral autonomic blocking action, nor does it produce extrapyramidal side effects; however, animals treated with diazepam do have a transient ataxia at higher doses. Diazepam was found to have transient cardiovascular depressor effects in dogs. Long-term experiments in rats revealed no disturbances of endocrine function. Injections into animals have produced localized irritation of tissue surrounding injection sites and some thickening of veins after intravenous use.
Valrelease
Absorption
Essentially complete, with a bioavailability of 93%.
Valrelease
side effects and Toxicity
Symptoms of overdose include somnolence, confusion, coma, and diminished reflexes. Respiration, pulse and blood pressure should be monitored.
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Patient Information
Valrelease
Organisms Affected
Humans and other mammals